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Research Outline      2014-10-15 11:01:59

1.Immunohistochemistry for Oral Lesions
This study used monoclonal and polyclonal antibodies and immunohistochemical method to assess the expression of oncogenes, tumor suppressor genes, growth factors, growth factor receptors and cytokeratins in oral premalignant lesions, oral cancers, salivary gland tumors, odontogenic cysts, and odontogenic tumors. The expression of these particular proteins was further correlated with oral habits, clinical parameters (patient's sex, age, tumor location, tumor size, lymph node metastasis, clinical staging), and histopathological parameters by statistical analysis. This study will help us to understand the malignant potential of oral premalignant lesions and the mechanisms of the development of oral lesions.
2.Photodynamic Diagnosis and Treatment of Oral Precancers and Oral cancers
Recently, we develop autofluorescence and ALA-induced protoporphyrine IX (PpIX) fluorescence spectroscopy to diagnose oral precancers (OPC) and oral cancers (OC). By means of autofluorescence spectroscopy at 330-nm excitation and ALA-induced PpIX fluorescence spectroscopy at 410-nm excitation, we can differentiate among oral submucous fibrosis, normal oral mucosa, OPC and OC. Therefore, autofluorescence and ALA-induced PpIX fluorescence spectroscopy can be used to determine the appropriate sites for biopsy in a large leukoplakia or erthroplakia lesion. In addition, the photodynamic therapy (PDT) with topical application of 20% ALA (topical ALA-PDT) can be used to treat OPC and OC. Our results indicate that topical ALA-PDT is very effective for treating verrucous hyperplasia and erythroleukoplakia and has a high potential to be used for treating verrucous carcinoma and early invasive squamous cell carcinoma.