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Pharmacology


Our major research fields are as follows:

  1. Cardiovascular system

    1. Search for agents against ischemia reperfusion heart injury, sepsis and diabetes.
    2. Systemic study on the mechanism of the anti-thrombotic agents and investigate the effects of snake venom components on blood coagulation.
    3. Discovering the anti-angiogenesis agents by investigating their effects on the proliferation and differentiation of vascular endothelial cells and smooth muscle cells.

  2. Neuroscience

    1. Search for the potential candidates to treat neuron degeneration diseases, including stroke, epilepsy, Parkisonism, Alzheimer's disease, pain sensation, neuron plasticity.
    2. Two novel neuropeptide systems (nociceptin/orphanin FQ and orexins/hypocretinis) are actively explored to investigate the molecular mechanism for several neural functions, including spinal analgesia, hyperphagia, depression, anxiolytic, hypolocomotion and learning and memory.

  3. Immune system

    1. Characterize the functions and signaling cascades of pathogen receptors (e.g. TLR, NOD-like receptor and C-type lectin receptors)
    2. Investigate the FcγRIIB signaling cascade to delineate the molecular basis of immune tolerance and discover the treatment of autoimmune disease.

  4. Cancer biology

    1. Search for the potential targets for cancer therapy
    2. Investigate the molecular pathways and epigenetic regulation that lead to the tumorigenesis and metastasis
    3. Explore the signal regulating pathways and intracellular mediators leading to cell death (e.g. apoptosis, necrosis and autophagic cell death)
    4. Investigate the pharmacological mechanisms of anti-cancer agents (e.g. natural products, synthetic compounds)

  5. Stem cell biology

    1. Establish the culture system to identify stem/progenitor cell population in different tissues
    2. Utilizing the regenerative capacity of stem cells to develop and repair tissues and organs