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Biochemistry and Molecular Biology

The main areas of research in this institute include the molecular mechanisms of cell growth, aging, and human diseases. The institute is composed of several groups including:

  1. Using proteomics approach to identify potential novel targets for drug development or as bio-markers of human disease such as cancer and infectious diseases.
  2. Molecular mechanisms involved in the multiplication and pathogenesis of human hepatitis viruses and SARS coronavirus.
  3. The development of hybrid core-shell nanostructures for theranostics.
  4. Using macromolecular X-ray crystallography, to study the structures and functions of proteins.
  5. To address how MMPs/ADAMTS inter play with heparan sulfate to modulate the extracellular matrix microenviroments which potentially affect cancer cells metastasis, cancer stem cell tumorigenesis or stem cell differentiation and proliferation.
  6. Identifying the molecular mechanisms which are involved in the progression of human cancer including lung, breast and prostate cancers.
  7. Creation and development of genetic technologies providing direct information on networks, pathways and dynamics of the complex system of protein acetylation/deacetylation in cultured human cells.
  8. Molecular mechanisms of interactions between hosts and pathogens, pathogenesis of tuberculosis.

Our institute is one of the pioneer groups in Taiwan, strongly encourage our research activity, set up collaborations with other group in studies of cancer and infections diseases. The development of novel approaches for preventing or controlling diseases, and in the elucidation of disease mechanism is our major missions.